Candida albicans Double Mutants Lacking both EFG1 and WOR1 Can Still Switch to Opaque
نویسندگان
چکیده
منابع مشابه
Wor1 establishes opaque cell fate through inhibition of the general co-repressor Tup1 in Candida albicans
The pathogenic fungus Candida albicans can undergo phenotypic switching between two heritable states: white and opaque. This phenotypic plasticity facilitates its colonization in distinct host niches. The master regulator WOR1 is exclusively expressed in opaque phase cells. Positive feedback regulation by Wor1 on the WOR1 promoter is essential for opaque formation, however the underlying mechan...
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Candida albicans, a commensal organism and a pathogen of humans, can switch stochastically between a white phase and an opaque phase without an intermediate phase. The white and opaque phases have distinct cell shapes and gene expression programs. Once switched, each phase is stable for many cell divisions. White-opaque switching is under a1-alpha2 repression and therefore only happens in a or ...
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Quorum sensing by farnesol in Candida albicans inhibits filamentation and may be directly related to its ability to cause both mucosal and systemic diseases. The Ras1-cyclic AMP signaling pathway is a target for farnesol inhibition. However, a clear understanding of the downstream effectors of the morphological farnesol response has yet to be unraveled. To address this issue, we screened a libr...
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ژورنال
عنوان ژورنال: mSphere
سال: 2020
ISSN: 2379-5042
DOI: 10.1128/msphere.00918-20